Phase 6 · Biometric & Longevity

Biological Age Calculator (PhenoAge)

Your blood panel knows how old you really are. Enter nine standard biomarkers and Levine's PhenoAge algorithm estimates your biological age — and what's driving it.

Educational estimate, not a diagnosis. PhenoAge is a research metric, not medical advice. Lab values vary by assay and a single panel is only a snapshot. Always review real results and health decisions with a licensed physician.

How do you calculate phenotypic age (PhenoAge)?

PhenoAge combines nine blood biomarkers — albumin, creatinine, glucose, C-reactive protein, lymphocyte percentage, mean cell volume, red cell distribution width, alkaline phosphatase and white blood cell count — with your chronological age into a mortality-risk score, which is then expressed as an age in years. A PhenoAge below your real age means your biomarkers look younger than your years.

Developed by Dr. Morgan Levine and colleagues (Levine et al., Aging, 2018) and validated against mortality in NHANES data.
All nine markers come from a standard blood panel: a complete blood count (CBC) plus a metabolic panel and a CRP test.
The figure that matters is the gap — PhenoAge minus chronological age. A negative gap is good.
Because the underlying markers are modifiable by diet, sleep, exercise and body composition, the score can improve over time.

Your blood panel

Nine biomarkers (US units) plus age. PhenoAge re-solves on every tick.

Chronological age 45 yr

Your actual age in years.

Albumin 4.7 g/dL

Liver/nutrition protein. Higher is generally better.

Creatinine 0.9 mg/dL

Kidney function marker.

Fasting glucose 90 mg/dL

Blood sugar. Lower (in range) is better.

C-reactive protein (CRP) 1 mg/L

Inflammation marker. Lower is better.

Lymphocyte % 32%

Share of white cells that are lymphocytes.

Mean cell volume (MCV) 90 fL

Average red blood cell size.

Red cell width (RDW) 13%

Variation in red cell size. Lower is better.

Alkaline phosphatase (ALP) 65 U/L

Liver/bone enzyme.

White blood cells (WBC) 6 K/µL

Immune cell count.

Phenotypic (biological) age

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From your nine biomarkers.

Chronological age

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Difference

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Aging pace

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10-yr risk score

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Under the hood

The algorithm, fully cited

We convert US units to the algorithm's clinical units, compute a linear predictor, a 10-year mortality score, then express it as an age:

xb = −19.907 − 0.0336·albumin + 0.0095·creatinine + 0.1953·glucose + 0.0954·ln(CRP) − 0.0120·lymph% + 0.0268·MCV + 0.3306·RDW + 0.00188·ALP + 0.0554·WBC + 0.0804·age

Mortality score M = 1 − exp( −e^xb · (e^0.0077·120 − 1) ÷ 0.0077 )

PhenoAge = 141.50 + ln(−0.00553 · ln(1 − M)) ÷ 0.090165

Source: Levine ME, Lu AT, Quach A, et al. "An epigenetic biomarker of aging for lifespan and healthspan." Aging (Albany NY). 2018;10(4):573–591. The PhenoAge biomarker model originates in Levine, J Gerontol A. 2013.
Unit conversions applied: albumin ×10 (g/dL→g/L), creatinine ×88.4 (mg/dL→µmol/L), glucose ÷18 (mg/dL→mmol/L), CRP ÷10 then natural log (mg/L→mg/dL).
What it means: a PhenoAge below your chronological age suggests biomarkers typical of a younger person; above it suggests accelerated aging. The trend over repeat panels matters more than any single number.

Your directives

What to do next, based on your numbers

Adjust the sliders to generate tailored recommendations.

Answers

Frequently asked questions

What is biological or phenotypic age?

Chronological age is how many years you've lived; biological age estimates how old your body appears to function. Two 45-year-olds can have very different biological ages depending on inflammation, metabolic health and organ function. Phenotypic age (PhenoAge) is a specific, validated estimate of biological age built from routine blood markers.

How is PhenoAge calculated?

PhenoAge, developed by Dr. Morgan Levine and colleagues, combines nine blood biomarkers (albumin, creatinine, glucose, C-reactive protein, lymphocyte %, mean cell volume, red cell distribution width, alkaline phosphatase and white blood cell count) plus your chronological age into a mortality-risk score, which is then expressed as an age. It has been shown to predict mortality and healthspan better than chronological age alone.

How do I calculate my phenotypic age?

Get a standard blood panel — a complete blood count (CBC) plus a metabolic panel and a CRP test cover all nine markers: albumin, creatinine, glucose, C-reactive protein, lymphocyte %, mean cell volume, red cell distribution width, alkaline phosphatase and white blood cell count. Enter those nine values plus your chronological age above, and the PhenoAge formula converts them into a mortality-risk score expressed as an age. This calculator runs Levine's published equation instantly, so you do not have to do the math by hand.

What does it mean if my phenotypic age is higher than my chronological age?

It means your biomarkers look "older" than your years — typically driven by elevated inflammation (CRP), high glucose, or other markers trending the wrong way — and is associated with higher health risk. A phenotypic age below your real age suggests your body is aging more slowly. The number to watch is the gap (PhenoAge minus your actual age): a negative gap is good, and because the underlying markers are modifiable, you can work to shrink a positive gap over time.

Can I actually lower my biological age?

The biomarkers behind PhenoAge respond to lifestyle: inflammation (CRP) falls with better diet, sleep, exercise and reduced visceral fat; glucose improves with weight loss and activity; RDW and others reflect nutrition. Because the score is built from these modifiable markers, improving them can genuinely lower your calculated PhenoAge over time. It is not fixed.

Is this a medical diagnosis?

No. This is an educational estimate of a research metric, not a diagnosis or medical advice. Lab values vary by assay and timing, and a single panel is a snapshot. Discuss your actual results, trends, and any concerns with a qualified physician — never make health decisions from a calculator alone.

Open the full Phenotypic Age (PhenoAge) calculator on EmpireCalc →